Epistemonikos is an important new innovation in the world of accessing evidence. Epistemonikos has become one of the largest databases of health evidence, a user friendly source that includes over 100,000 systematic reviews and hundreds of thousands of individual studies. Apart from the amount of information, Epistemonikos is unique in a number of ways. First, it caters to non-English speaking users – you can conduct your search in any of 9 languages. Second, a “matrix of evidence” tool facilitates quick searching and updating. The tool identifies all systematic reviews that address a particular question, and all the studies included in those reviews, displaying a cross-tabulation of reviews and studies. It also allows you to stay up to date: after you save your search, any new review will appear automatically.